FOXO4-DRI peptide is a modified peptide that researchers use to study cellular senescence in laboratory models. Simple Peptide sells it as a lyophilized research material, and every batch has a published certificate of analysis. You can review the full listing on the FOXO4-DRI product page.
FOXO4-DRI
FOXO4-DRI is a D-retro-inverso peptide that researchers use to block the binding between the FOXO4 and p53 proteins in senescent cell models. It uses D-amino acids in reverse order. This design also makes it more resistant to breakdown by enzymes in lab conditions.
You may also see the name written as “FOX04-DRI,” with a zero in place of the letter O. That typo is common in search results and on forums. However, it refers to the same compound, so our catalog lists it under the correct name with the letter O.
Why the FOXO4 and p53 link matters to researchers
In senescent cells, FOXO4 can bind p53 and hold it in the nucleus. Researchers study what happens when a FOXO4-DRI peptide disrupts that binding. For example, a widely cited 2017 study used the compound in senescence research models and sparked many follow-up papers. To read the literature yourself, start with a PubMed search for FOXO4-DRI.
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A clear path from order to bench
Picture a postdoc who plans a senescence assay and needs a FOXO4-DRI peptide this month. The last vendor sent a vial with a label but no lab report, so the team could not confirm the batch. At Simple Peptide, we solve that problem up front. First, an independent lab tests every batch. Next, we post the results on our COA page. Then you match the batch number on your vial to that report. As a result, your records stay complete, and your team can start the assay on schedule.
Consistency also matters across long projects. A senescence study can run for months, and a change in source material can add noise to the data. Therefore, many labs prefer to buy each FOXO4-DRI peptide vial from one supplier with batch-level testing.
Related longevity research peptides
Meanwhile, labs that study senescence often keep other compounds in the same freezer. For instance, Epitalon 10MG is a short tetrapeptide that researchers study in telomerase research. Likewise, MOTS-C is a mitochondrial-derived peptide that labs study in metabolic research models. In addition, PE-22-28 10mg is a spadin-derived peptide that researchers study in TREK-1 channel models. You can browse the full group in our longevity category.
Why labs order FOXO4-DRI peptide from Simple Peptide
First, we run a US-based store, and we describe our products as US manufactured research peptides. Our shipping and returns page lays out the policies in plain words. Also, our team answers questions through the contact page. For larger programs, our wholesale page explains bulk accounts. In short, you receive tested material, clear policies, and a real team behind each FOXO4-DRI peptide order.
Frequently asked questions
What is a FOXO4-DRI peptide?
It is a D-retro-inverso peptide that researchers use to study the FOXO4 and p53 interaction in senescent cell models.
Is FOX04-DRI the same as FOXO4-DRI?
Yes. “FOX04-DRI” uses a zero instead of the letter O. It is a common typo for the same compound.
Where can I see the test results for my batch?
We publish every batch report on our COA page. Match the batch number on your vial to the matching report.
How should labs store lyophilized FOXO4-DRI?
Most labs keep sealed vials cold, dry, and away from light. They also log the batch number and the date they first open each vial.
Disclaimer: Simple Peptide sells all products for laboratory research use only. They are not for human consumption, and nothing on this page is medical advice.